Most men would do anything to get out of Fox River Penitentiary, but Michael Scofield will do anything to get in. His brother Lincoln is on death row accused of a crime he didn't commit, and the only way to save him is from the inside out. Armed with the prison blueprints and an intricate escape plan, Michael gets him arrested, beginning a race against time. Now, he will need all the cunning, courage and luck he can muster, as well as the help of some of the most heinous and dangerous inmates.
Going over the wall and on the run, America's most wanted men, Michael Scofield and his brother Lincoln Burrows, must lead a dangerous band of hardened fugitives on a desperate international flight in search of millions of dollars, risking everything to unmask a sinister government conspiracy, and desperately fighting to stay alive until the day they can stop running.
Escape from Fox River maximum security prison was the easy part. Now, Michael Scofield must fight to survive in Sona, a hellish prison in Panama where the only rule is brutal violence and the only escape is in a body bag. So, and with time running out, Lincoln Burrows fights desperately to save his brother along with the only man who can free his son from the Company's fearsome clutches.
In order to destroy the sinister organization known as "The Company," Michael Scofield and his brother must escape a ruthless killer and discover the terrible secret behind the mysterious device called Scylla. Lives are destroyed and tension builds as everything comes together in a surprising outcome, as Michael and Lincoln fight for survival until the day they can stop running - forever
Many things have changed in these seven years: Lincoln has resumed his old life and is once again in debt to drug dealers; Sara has married Jacob, with whom she raises her son with Michael; and C-Note has converted to Islam.